Damon Lindelof: "Hey, a bunch of humans seeking out their creator. David knows exactly who created him, and he is not impressed by his creator."
Ridley Scott: "I do despair. That's a heavy word, but picking up a newspaper every day, how can you not despair at what's happening in the world, and how we're represented as human beings? The disappointments and corruption are dismaying at every level. And the biggest source of evil is of course religion. [...] Everyone is tearing each other apart in the name of their personal god. And the irony is, by definition, they're probably worshipping the same god. [...] I'm really intrigued by those eternal questions of creation and belief and faith. I don't care who you are, it's what we all think about. It's in the back of all our minds." Source: Esquire
Damon Lindelof: "I'm most definitively pro-science, but I think that the movie advances the idea that, can the two live along side each other? Is it possible to be a scientist and maintain some fungible faith in the unknown? And are you rewarded for having blind faith? I do think that the movie is making the meta-commentary in saying well Shaw is the true believer on board, and she's the one who survives. So what are we trying to say by telling that story?" Source: io9.com