"We now have seven confirmed cases in total," said Hadebe.
"Three new cases were confirmed over the weekend."
The fifth and sixth patient are believed to be displaying mild symptoms and the department was still gathering information on the seventh patient's condition.
The third and fourth cases, which were confirmed on Friday, were of patients who had travelled from London and the United States.
Their treatment is being managed at home in accordance with WHO and health department guidelines and people they were in contact with will be consulted.
Among the seven cases, is rugby player Brian Liebenberg, according to Beeld newspaper.
"To prevent spread, people who are ill should cover their mouth and nose when coughing or sneezing, stay home when they are unwell, clean their hands regularly, and keep some distance from healthy people, as much as possible."